Podrobnosti o izdelku
Poglej vseISBN
9781607611318Mladinska knjiga ID
399601Leto izida
2009Datum izida
30.08.2009Velikost (šxdxv)
150 × 200 × 10Status dobavljivosti
Na zalogi pri dobaviteljuJezik
ANGZaložnik
SPRINGER-VERLAG GmbHAvtor
DOMINGUEZ BENDALAOpis
Offers a comprehensive review of the development in both pancreatic development and regeneration. This book discusses the many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells in the context of potential therapeutic interventions for type I diabetes.From the discovery of Pdx1, the first 'master gene' of pancreatic development, to the most recent findings on the role of microRNAs in beta cell homeostasis, the last fifteen years have seen an unprecedented advance in our understanding of the precise development and organization of the many different cell types that make up the pancreas. It is now widely acknowledged that the therapeutic differentiation of stem cells into pancreatic cells is an ambitious endeavor that will not succeed without a thorough understanding of the molecular processes underlying the native development of the organ. This book, aimed at experts and students alike, offers a comprehensive review of the state of the art in both pancreatic development and regeneration. The many strategies to differentiate adult and embryonic stem cells into pancreatic beta cells are also discussed in the context of potential therapeutic interventions for type I diabetes.Table of Contents: Preface. Importance of the subject in the context of type I diabetes (2-3 pages) The pancreas (15 pages) Pancreatic development (50-60 pages) Pancreatic regeneration (30-40 pages) Models of regeneration Stem cells vs. beta cell replication Stem cell differentiation: general approaches (20-30 pages) Recapitulation of pancreatic development Signal-driven strategies Gene transfer and protein transduction Physiological variables Embryonic stem cells and pancreatic differentiation (40 pages) Adult stem cells and pancreatic differentiation (60 pages) Bone marrow Umbilical cord Ductal and acinar cells Mesenchymal stem cells and de-differentiation Transdifferentiation (30 pages) Remaining challenges and clinical perspectives (20-30 pages)
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