Podrobnosti o izdelku
Poglej vseISBN
9781934115046Mladinska knjiga ID
399521Leto izida
2008Datum izida
30.11.2008Velikost (šxdxv)
150 × 200 × 10Status dobavljivosti
Na zalogi pri dobaviteljuJezik
ANGTeža
300 gZaložnik
SPRINGER-VERLAG GmbHAvtor
, COHENOpis
Offers guidance for conducting pharmacogenomic research from discovery to the market, presenting a realistic perspective on the challenges, practicalities and obstacles in its application. This title assists investigators in the understanding of the scientific challenges in applying pharmacogenomics to drug discovery and clinical development.Preface Contributors Challenges, Opportunities and Evolving Landscape in Pharmacogenomics and Personalized Medicine: An Industry PerspectiveNadine Cohen and Theresa Frangiosa Considerations for Sample Collections Intended for Pharmacogenomic analyses: The Pharmacogenomics protocol and informed consent form Deborah Ricci and Monique Franc Pharmacogenomics: The Regulatory Environment and Labeling ImplicationMyong-Jin Kim, Shiew-Mei Huang, Atiqur Rahman, Felix W. Frueh, Lawrence J. Lesko Applications of Pharmacogenomics in Drug DiscoveryDuncan McHale Applications of Pharmacogenomics in Clinical TrialsMonique Franc Pharmacogenomics applications in drug metabolism: from genotyping to druglabel-challenges?Ann K. Daly The Genetics of Adverse Drug Reactions -- Promises and ProblemsMartin Armstrong Strategies and resources for marker selection and genotyping in genetic association studiesNicole Soranzo, Dong-Jing Fu and Qingqin S. Li Study Design and Statistical Methods in Pharmacogenomics Research: From Candidate Genes to Genome Wide ScreensNicholas J. Schork, Nathalie Malo, Eric J. Topol Holy SNP, Batman! Reyna Favis Use of Predictive Biomarker Classifiers in the Design of Pivotal Clinical TrialsRichard Simon Translation of biomarkers into clinical utility William Trepicchio and George Mulligan Pharmacogenomic Study Feasibility Assessment and Pharmaceutical Business Decision-MakingMonique Franc and Theresa Frangiosa Co-development of drugs and Pharmacogenomics based Diagnostics in Oncology Jeffrey Ross Pharmacogenomics applications in Epilepsy Chantal Depondt Pharmacogenomics in Alzheimer's DiseaseRamon Cacabelos Pharmacogenomics applications in Psychiatric disorders Todd Lencz and Anil K. Malhotra Pharmacogenomics in HIV DiseaseAmalio Telenti Pharmacogenomics and Cardiovascular Drugs Gerard Siest, Hind Berrahmoune, Jean-Brice Marteau,and Sophie Visvikis-Siest Pharmacogenomic applications in Children Struan F.A. Grant and Hakon Hakonarson Pharmacogenomics of rare and monogenic disorders Paul Maher
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